I have been doing a LOT of reading about this covid thing. I know, I know, Me and half the planet, right? And like everyone doing reading I have some thoughts. So, I want to put them all together here in see what if anything folks have to say about it. . . .
*Note: This post is littered with links to much of the things I've read. But for every link posted, I have read at least 5-6 other journal articles, papers, and sites. for the most part, if its not a full on research paper published by a reputable source, I generally discount it. If I've linked to something that isn't one of those, its because that link did a better job at synthesizing multiple other sources than I had time to do.
Disclosures:
In full disclosure, I am not a scientist by profession. Instead, I am a lawyer. And a lawyer is above all, a researcher. To that end I spend much of my waking day soaking up information like a sponge. From waking up to news radio, to reading and watching the TED before tucking in at night I am in constant learning and thinking mode. Additionally, I am an admitted nerd, much to my spouse’s chagrin, I’m certain. So my light reading is often medical journals. *Note: This post is littered with links to much of the things I've read. But for every link posted, I have read at least 5-6 other journal articles, papers, and sites. for the most part, if its not a full on research paper published by a reputable source, I generally discount it. If I've linked to something that isn't one of those, its because that link did a better job at synthesizing multiple other sources than I had time to do.
Disclosures:
And now the Lawyer part:
The following blog post may contain graphic content, viewer discretion is advised. This post does not, does not seek to, nor intend to, nor even remotely suggest or dispense any medical advice. Nor does it advocate the use of any medication, herbs, supplements, topicals, or spiritual practices, substances, or products for the treatment or, relief from, any medical condition. If you feel that you need medical advice please consult your appropriate physician. Some assembly required. Batteries not included. Results may vary, and; If this is an emergency please hang up and dial 911.
Now for the real reason you’re clearly glued to this screen.
Setting the stage:
As Covid-19 spread in China, researchers across all of Asia began looking at all possibilities to treat people suffering from this illness. At Wuhan University for instance, they began testing antiretroviral drugs. Particularly they tested protease inhibitors that have been successful at treating HIV and hepatitis C. Spain then began testing antiretroviral drugs as well. Both have had a measure of success. I’ll discuss the whys below.
Chinese clinicians and researchers in multiple provinces saw a series of patients experience lessened effects of Covid-19 after treatment with anti malarial drugs. Particularly with variants of Chloroquine. The science hadn’t been fully established as to why this phenomenon occurred however. Nor had it been peer reviewed. Nor had it been replicated in a double blind study of more than a 1500 person sample size. All of those steps are essential to biomedical science. And also essential to the application of the scientific method to the art of medicine. We generally do this to insure the efficacy of treatments to avoid snake oils and hurting people. And we usually do these things before announcing a “cure." (Note to President Trump, if you’re reading this.)
Because Covid-19 has been racing out of control and killing people, clinicians the world over have had far more leeway to use existing treatments and medicines with off label uses in an effort to see if they will help combat Covid-19. This has produced a lot of anecdotal data for which to give us general direction and guidance when planning actual double blind scientifically controlled studies.
What has been really interesting are the multiple directions the research is going all simultaneously it is a such a testament to the vast world resources being deployed on this medical problem. It's really amazing!
What has been really interesting are the multiple directions the research is going all simultaneously it is a such a testament to the vast world resources being deployed on this medical problem. It's really amazing!
The Chemistry of Covid-19 - Scratching the Surface
A few days ago my uncle Charlie in Florida posted a piece where a person attempted to explain the organic chemistry behind why hydroxyChloroquine seems to provide relief from Covid-19 symptoms.
The hypotheses of that individual was two pronged. It stated:
1. Covid-19 seems to be depriving the body of O2 and that it seemed to be doing so by hijacking heme. In a manner not unlike how malaria attacks the body.
2. Anti Malarials seemed to work on first trial in China and India.
The hypotheses of that individual was two pronged. It stated:
1. Covid-19 seems to be depriving the body of O2 and that it seemed to be doing so by hijacking heme. In a manner not unlike how malaria attacks the body.
2. Anti Malarials seemed to work on first trial in China and India.
If this guy is right, then wouldn’t any treatment that prevented heme rupture toxicity, stopped putting free FeO into the blood stream, and that maintained the body’s Fe2 to Fe3 exchange system in the avioli result in a similar successful outcome? Here's something I read to learn more on that.
I found myself intrigued and curious if the guy was bullshitting or did his chemistry check out. So I started looking at how does chloroquine work on the body from an organic chemistry perspective.
To start with I wanted to know what malaria does to the body. What Covid-19 does, And then how chloroquine works on the body to counteract against the effects of malaria. Turns out, it seems to be less about how Malaria works and more about how Clorquine works in conjunction with Zinc and what that actually does. (More on that later)
Digging Deeper
Here’s what I found. Researchers in China determined that "COVID-19: Attacks the 1-Beta Chain of Hemoglobin and Captures the Porphyrin to Inhibit Human Heme Metabolism" The abstract from that journal article states in pertinent part:
As the News Media started to pick up on that article they began to disseminate it so that other Doctors and researchers could use it the information.
Scientists demonstrate how COVID-19 infects human cells
Scientists demonstrate how COVID-19 infects human cells
Which also prompted another paper to challenge the first.
Flawed methods in “COVID-19: Attacks the 1-Beta Chain of Hemoglobin and Captures the Porphyrin to Inhibit Human Heme Metabolism”
Then partitioners started reporting from the field.
Overall however This was a really good blog thread of medical researchers and nerds was pretty helpful and I felt it was the most intriguing because of the folks on it and the many links that they shared.
Key Take Aways From That blog thread.
- The folks there seemed to posit that Zinc and Vitamin C might act as an antiviral to reduce a Virus' effects on the human body.
A Series of Interesting Videos
Here are the observations of a Dr. In NYC: He is convinced that this is NOT a regular pnemonia and that it is basically a O2 related disease kind of like Hypoxia. He comes into play later with other treatment options.
A Theory about Vitamin C and Chaga Mushrooms
Now this guy thinks this is a Bio weapon and he has been reviewing SARS 1 research, and then conflates some SARS 1 research with SARS 2 (Covid 19) (he has another video where he explains how he thinks that SARS 1 research led to SARS 2 development) yeah yeah. . he's a lil tin foil hat. . BUT his ability to synthesize some of this information is pretty good, and having gone back and tried to recreate his research chain from this video for each of his claims has shown me that he's not entirely off base.
https://www.youtube.com/watch?v=fw4CcQg_1z4
Ultimately he's convinced that Vitamin C is the answer. And he thinks that Chaga Mushrooms are the supplement that will do it. Because the Chaga Mushrooms have high Vitamin C. Furthermore there are some interesting papers on Chaga Mushrooms, including this one.
Trying Lupus Drugs for Covid -19 Symptom Relief
from what I've read about Lupus, Lupus is an auto immune disease that "tricks the body" into thinking that its under disease attack and thus pushes the body's immune system into overdrive and then the body floods itself with cytokines in order to fight the perceived disease. Lupus drugs such as Hydroxy Chloroquine reduce the Cytokine storms that are caused by Lupus. Since Covid 19 seems to cause similar cytokine storms in some patients (See Also Web M.D. Article on this) the idea that Lupus and malarial drugs would reduce the cytokine storms led to the use of trying them out. To that end some practitioners in TX are trying Plaquenil (Hydroxyclorquine). ie. this would reduce the edema. At the very least it seems to be working in some patients. I kind of geeked out on how these drugs metabolise in the following way: Cytochrome P450 2C8 and CYP3A4/5 are involved in chloroquine metabolism in human liver microsomes.
Trying Altitude Sickness Drugs
In response to the Dr. in NYC describing this thing more as Hypoxemia than pnemonia there were multiple folks to posited that maybe then the answer is altitude sickness medication. To that a lady posted a video on Youtube with her ideas about it. In response to that several physicians pipped up and claimed, wait, these haven't been tested, therefore it can't work. nevertheless some off label treatment seems to be happening out there in response to this being a dire situation world wide and researchers and clinicians being desperate to help their patients.
What about Kratom? Im curious. . . .
In recent months I have been doing some legal work around Kratom (Mitragyna Speciosa). Kratom has been used for centuries in South East Asia, India, and the Philippines primarily for pain management and mood stabilisation, but also as an anti-malarial. Kratom isn't new in the U.S. it has been around and been studied since the 1960's. Apparently it may have some anti-inflamatory properties as well. High in Vitamin C? Maybe. . .. who knows. . . But, At least one professor in Indonesia posited the possible use of Kratom to reduce the effects of Covid-19.
The US. Federal Trade Commission immediately jumped all over a company that talked about this professor's presentation on their website, and claimed that the company made unfounded medial claims about kratom. (see FTC letter). That being said, I read what the company wrote (the FTC put it in their letter) and it was interesting that the FTC actually cited them for their citing well known scientific facts in some instances. I mean, even Wikipedia has the information. I thought that was pretty odd. But hey, if the federal government wants to silence folks to keep people from disseminating potential information that clinicians and researchers could use to do good science, then who am I to bother them about it. John Q Citizen should just not say anything apparently and should keep his mouth shut. . . . hmmmm
All that being said I still geeked out on a Paper on Inhibitory effect of mitragynine on human cytochrome P450 enzyme activities. Particularly the finding that: "The findings of this study reveal that mitragynine might inhibit cytochrome P450 enzyme activities, specifically CYP2D6." I mean, don't ALL herbals affect the body and don't they all have a potential to interact with any thing else that uses the same metobolic pathway? It seems pretty self explanatory.
It made me wonder if there were any groups of folks out that that tried kratom, the same way that the Youtube guy claimed a group tried Chaga Mushrooms? And if so what are they reporting anecdotally?
AntiRetrovirals
Spain began a trial in Barcelona and in Seville on using HIV drugs to combat Covid-19. China Also began trials. U.C. Berkely had some success as well.
All that being said I still geeked out on a Paper on Inhibitory effect of mitragynine on human cytochrome P450 enzyme activities. Particularly the finding that: "The findings of this study reveal that mitragynine might inhibit cytochrome P450 enzyme activities, specifically CYP2D6." I mean, don't ALL herbals affect the body and don't they all have a potential to interact with any thing else that uses the same metobolic pathway? It seems pretty self explanatory.
It made me wonder if there were any groups of folks out that that tried kratom, the same way that the Youtube guy claimed a group tried Chaga Mushrooms? And if so what are they reporting anecdotally?
AntiRetrovirals
Spain began a trial in Barcelona and in Seville on using HIV drugs to combat Covid-19. China Also began trials. U.C. Berkely had some success as well.
My Key Take Away's from all my readings.
- The experts just DO NOT know what this damn thing is exactly.
- The experts know a lot about it but not everything.
- The experts are still grappling for answers on how best to combat this damn virus.
- The virus seems to deprive/starve people of oxygen.
- The virus seems to create agitation and inflammation in the lungs.
- People on ventilators don't seem to fair too well.
- The more we learn about chloroquine the less it seems to be working by itself and it seems to have dangerous side effects.
- Things that reduce viral load and reduce a virus' ability to replicate or infect other cells seem to be effective at slowing it down within a patient or reducing its effects on the body.
- Vitamin C, Zinc, Antiretrovirals, and Chloroquine have all been tried with varying degrees of success.
- There may be some other drugs or herbals out there that haven't yet been tried but that have similar chemical properties, and might have some efficacy in combatting the virus.
SOOO, for all my reading and time involved. I'm really no better off if I catch Covid-19. . . unless of course I have a stash of Vitamin C, Zinc, Chaga Mushrooms, Azithromyacin, Kratom, Altitude sickness drugs, Hydroxy Chloroquine, and Antiretrovirals, and then who knows if they'll work . . it seems I better download some mask patterns and bust out the old singer. . .
